英国伦敦玛丽女王大学 Dr. Emma Chambers 实验室招收 QMUL-CSC 公 派博士生。

libo19950402

Invitation for applications for QMUL-CSC PhD Projects
Supervised by Dr. Emma Chambers, Centre for Immunobiology, Blizard institute, QMUL
Research Theme: anti-bacterial and anti-fungal cutaneous immunity changes
with age
英国伦敦玛丽女王大学 Dr. Emma Chambers 实验室招收 QMUL-CSC 公
派博士生。
伦敦玛丽女王大学 (Queen Mary University of London，QMUL)，1887 年建立于英
国首都伦敦，是一所享誉世界的公立综合研究型大学。伦敦玛丽女王大学为英国精英
大学联盟罗素大学集团成员之一，并与牛津大学、剑桥大学、伦敦大学学院、伦敦帝
国理工学院、南安普顿大学共建科学与工程南联盟。伦敦玛丽女王大学拥有伦敦地区
最大的校园，其主校园位于伦敦东部的麦尔安德(Mile End Campus)。伦敦大学玛丽女
王大学的校友和教员中不乏英国皇家学会、英国科学院和皇家工程院院士，共诞生了
9名诺尔奖得主。玛丽女王大学在 REF-2014科研实力的评估中，科研输出在全英国排
名第五。2021 最新泰晤士高等教育世界大学排名(QS World University Ranking)114
位。玛丽女王大学十分注重国际发展和合作，在国际展望部分的排名世界前 20 位。
Dr. Emma Chambers 博士后期间师从于 Prof. Arne Akbar (University College
London),主要研究衰老伴随的免疫衰退相关课题：通过降低机体慢性炎症反应增强老
年人群对抗原特异性免疫能力。2020 年 Dr. Emma 获得 Bart’s Charity lectureship 并
在 Centre for Immunobiology，Blizard Institute，QMUL 组建实验室团队。目前团队有
全职博士后一名，期待新成员的加入共同参与衰老相关的免疫课题研究。
实验室链接：https:// w w w . q m u l . a c . u k /blizard/staff/centre-forimmunobiology/staff/wwwqmulacukblizardall-staffprofilesemma-chambers.html
申请者要求：
1. 候选者需要有相关领域的硕士/本科学历（细胞/分子生物学，生物化学，生命科
学或生物学）。
2. 有实验室学习或者工作经验，具备独立完成实验任务的能力和团队协作精神。
3. 拥有免疫生物学相关的背景和实验技术将被优先考虑但并非必须，相关实验技
术（比如：流式细胞术）会有专业人员加以培训。
4. 英语水平：雅思总分不低于 6.5。其中写作单项不低于 6；阅读，听力和口语不
低于 5.5。
具体申请要求请参看：https:// ww w.qm u l.ac.uk/scholarships/items/chinascholarship-council-scholarships.h t m l
申请截止日期：2021 年 1 月 27 日（2021 年 9 月入学）。
进一步了解其他信息，请发邮件（附 CV）到 Dr. Emma Chambers
(e m m a . c h a m b e r s @ q m u l . a c . u k ) 并抄送 D r .   W e i g a n g   C a i   ( w . c a i @  q mu l .  ac . u k ) .
此外实验室也有意招收访问学者及 self-funded 博士生，欢迎邮件咨询。Invitation for applications for QMUL-CSC PhD Research Projects
Supervised by Dr. Emma Chambers, Blizard institute, QMUL
Research Theme: anti-bacterial and anti-fungal cutaneous immunity changes with age
Atgeing is a global burden. However with increasing life-span there is not increasing
“Health-span”, people are living longer with chronic diseases and infection impacting on
their quality of life. Ageing negatively impacts upon many aspects of a functional immune
response, leading to: increased infections; re-activation of latent infections; decreased
vaccine efficacy; and increased incidence of cancer. An aging population also causes a
huge financial burden, and targeting age-related immune defects has exciting therapeutic
potential. Therefore, this study on immunity changes with age will help us better
understand the ageing process, improve personal life quality and maintain sustainable
social/economic system.
Previously, it was observed that there is reduced cutaneous recall responses to in older
adults as compared to young (Agius et al 2009). This defect in antigen-specific immunity
is due to non-specific monocyte-derived inflammatory response to needle challenge (ES
Chambers et al 2020). Blockade of this inflammatory response using the anti-inflammatory
drug Losmapimod significantly improves antigen-specific immunity in older adults
(Vukmanovic-Stejic and Chambers et al 2018).
Therefore, the overarching aim of this project is to understand if immunological
defects in cutaneous immunity negatively affect anti-fungal (Candida albicans) and antibacterial (E.coli) immunity. This research is unique as it is the first to look at the
contribution of monocytes to inflammageing process and decreased antigen-specific
cutaneous immunity. In this project, we will focus on answering the three specific
questions below:
1. How does cutaneous immunity to
Candida albicans and E.coli change
with age?
2. Do peripheral monocytes change in
phenotype and function with age?
3. How does the interaction between
Foxp3+Tregs and monocytes
impact antigen-specific immunity?
Principally, this project builds upon Dr. Emma Chambers extensive experience in
experimental human skin systems, and will carry out in-depth analysis of the cutaneous
immune response over time in vivo in humans (ES Chambers et al 2020).
The candidate need have a master/bachelor degree in relevant field (e.g. cell/molecular
biology, biochemistry or life/biological sciences), working experience in a scientific
laboratory, the capacity to work independently, thinking creatively and a demonstrated
ability to work as part of a team. Some experience in immunobiology techniques would be
valuable but not essential. Training in a range of immunobiology techniques (e.g. Flow
cytometry) will be provided. Training in writing and communication skills will be provided,
complemented with transferable skills training from the Queen Mary University of London
(QMUL) Learning Institute.
English language requirement: Academic IELTS: 6.5 overall, with a minimum of 6.0 in
writing and a minimum of 5.5 in reading, speaking and listening.
For more information contact Dr. Emma Chambers ( e m m a . c h a m b e r s @ q m u l . a c . u k ) and Dr.
Weigang Cai (w . c a i @ q m u l . a c . u k ).